Chimeric antigen receptor (CAR) T cells use re-engineered cell surface receptors to
specifically bind to and lyse oncogenic cells. Two clinically approved CAR-T–cell therapies …

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved
in innate immune responses to fungal pathogens. This transmembrane signalling receptor …

Dectin-1 is a lectin receptor for β-glucan that is important for innate macrophage recognition
of fungi and contributes to phagocytosis, reactive oxygen production, and induction of …

The skeleton and the immune system share a variety of different cytokines and transcription
factors, thereby mutually influencing each other. These interactions are not confined to the …

Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the
degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two …

The human genome encodes more than 300 potential immune inhibitory receptors. The
reason for this large number of receptors remains unclear. We suggest that inhibitory …

Engineered T cells that express chimeric antigen receptors (CARs) have transformed the
treatment of haematological cancers. CARs combine the tumour-antigen-binding function of …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

The T cell antigen receptor (TCR) contains ten immunoreceptor tyrosine-based activation
motif (ITAM) signaling sequences distributed within six CD3 subunits; however, the reason …

In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in
vitro and in vivo. Syk−/− osteoclasts fail to organize their cytoskeleton, and, as such, their …