Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction

JG Paithankar, S Saini, S Dwivedi, A Sharma… - Chemosphere, 2021 - Elsevier
Heavy metal-induced cellular and organismal toxicity have become a major health concern
in biomedical science. Indiscriminate use of heavy metals in different sectors, such as …

[HTML][HTML] Disease-associated metabolic pathways affected by heavy metals and metalloid

Z Haidar, K Fatema, SS Shoily, AA Sajib - Toxicology Reports, 2023 - Elsevier
Increased exposure to environmental heavy metals and metalloids and their associated
toxicities has become a major threat to human health. Hence, the association of these …

[HTML][HTML] Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Reactive oxygen species and cancer paradox: To promote or to suppress?

S Galadari, A Rahman, S Pallichankandy… - Free Radical Biology …, 2017 - Elsevier
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Estimation of health risks associated with dietary cadmium exposure

S Satarug, DA Vesey, GC Gobe, KR Phelps - Archives of Toxicology, 2023 - Springer
In much of the world, currently employed upper limits of tolerable intake and acceptable
excretion of cadmium (Cd)(ECd/Ecr) are 0.83 µg/kg body weight/day and 5.24 µg/g …

Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals

S Prasad, SC Gupta, AK Tyagi - Cancer letters, 2017 - Elsevier
Extensive research over the past half a century indicates that reactive oxygen species (ROS)
play an important role in cancer. Although low levels of ROS can be beneficial, excessive …

Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases

IT Lee, CM Yang - Biochemical pharmacology, 2012 - Elsevier
Reactive oxygen species (ROS) are products of normal cellular metabolism and are known
to act as second messengers. Under physiological conditions, ROS participate in …

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF

J Cheng, HL Yang, CJ Gu, YK Liu… - International …, 2019 - spandidos-publications.com
Angiogenesis is an essential process involved in various physiological, including
placentation, and pathological, including cancer and endometriosis, processes. Melatonin …

Oxidative stress and metal carcinogenesis

JC Lee, YO Son, P Pratheeshkumar, X Shi - Free radical biology and …, 2012 - Elsevier
Occupational and environmental exposures to metals are closely associated with an
increased risk of various cancers. Although carcinogenesis caused by metals has been …

Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer

F Agani, BH Jiang - Current cancer drug targets, 2013 - ingentaconnect.com
Studies on erythropoietin regulation led to discovery of hypoxia-inducible factor 1 (HIF-1), a
transcription factor which is central component of oxygen sensing mechanism in mammalian …