Multiple instance learning: A survey of problem characteristics and applications
Multiple instance learning (MIL) is a form of weakly supervised learning where training
instances are arranged in sets, called bags, and a label is provided for the entire bag. This …
instances are arranged in sets, called bags, and a label is provided for the entire bag. This …
[HTML][HTML] Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing
Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA
molecules from a single pre-mRNA with a prominent role in the development and function of …
molecules from a single pre-mRNA with a prominent role in the development and function of …
Bridging the splicing gap in human genetics with long-read RNA sequencing: finding the protein isoform drivers of disease
Aberrant splicing underlies many human diseases, including cancer, cardiovascular
diseases and neurological disorders. Genome-wide map** of splicing quantitative trait …
diseases and neurological disorders. Genome-wide map** of splicing quantitative trait …
The emerging era of genomic data integration for analyzing splice isoform function
The vast majority of multi-exon genes in humans undergo alternative splicing, which greatly
increases the functional diversity of protein species. Predicting functions at the isoform level …
increases the functional diversity of protein species. Predicting functions at the isoform level …
FFPred 3: feature-based function prediction for all Gene Ontology domains
Predicting protein function has been a major goal of bioinformatics for several decades, and
it has gained fresh momentum thanks to recent community-wide blind tests aimed at …
it has gained fresh momentum thanks to recent community-wide blind tests aimed at …
Alternative splicing and gene expression play contrasting roles in the parallel phenotypic evolution of a salmonid fish
Understanding the contribution of different molecular processes to evolution and
development is crucial for identifying the mechanisms of adaptation. Here, we used RNA …
development is crucial for identifying the mechanisms of adaptation. Here, we used RNA …
Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors
Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …
nervous system. Increasing evidence indicates that developmental and tissue-dependent …
Assessing the functional relevance of splice isoforms
Alternative splicing of messenger RNA can generate an array of mature transcripts, but it is
not clear how many go on to produce functionally relevant protein isoforms. There is only …
not clear how many go on to produce functionally relevant protein isoforms. There is only …
DIFFUSE: predicting isoform functions from sequences and expression profiles via deep learning
Motivation Alternative splicing generates multiple isoforms from a single gene, greatly
increasing the functional diversity of a genome. Although gene functions have been well …
increasing the functional diversity of a genome. Although gene functions have been well …
ProMIL: Probabilistic multiple instance learning for medical imaging
Abstract Multiple Instance Learning (MIL) is a weakly-supervised problem in which one label
is assigned to the whole bag of instances. An important class of MIL models is instance …
is assigned to the whole bag of instances. An important class of MIL models is instance …