Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation
Aim: The aim of this study was to develop gastroretentive mucoadhesive pellets of Orlistat to
improve its oral bioavailability and enhance its absorption. Methods: Orlistat pellets were …
improve its oral bioavailability and enhance its absorption. Methods: Orlistat pellets were …
[HTML][HTML] Effect of process parameters in high shear granulation on characteristics of a novel co-processed mesoporous silica material
A Baumgartner, O Planinšek - European Journal of Pharmaceutical …, 2023 - Elsevier
In this study, insights into the development and optimization of a co-processed excipient
based on mesoporous silica are presented. The main advantage of such a material is that it …
based on mesoporous silica are presented. The main advantage of such a material is that it …
[HTML][HTML] Continuous integrated production of glucose granules with enhanced flowability and tabletability
Glucose is widely used in both the food and pharmaceutical industry. However, the
application of industrially crystallized glucose in solid dosage forms is challenged by its poor …
application of industrially crystallized glucose in solid dosage forms is challenged by its poor …
Design space approach for the optimization of green fluidized bed granulation process in the granulation of a poorly water-soluble fenofibrate using design of …
In the pharmaceutical industry, the systematic optimization of process variables using a
quality-by-design (QbD) approach is highly precise, economic and ensures product quality …
quality-by-design (QbD) approach is highly precise, economic and ensures product quality …
[HTML][HTML] Integrated continuous melt granulation-based powder-to-tablet line: Process investigation and scale-up on the same equipment
In the last decades, continuous manufacturing (CM) has become a research priority in the
pharmaceutical industry. However, significantly fewer scientific researches address the …
pharmaceutical industry. However, significantly fewer scientific researches address the …
Exploitation of design-of-experiment approach for design and optimization of fast-disintegrating tablets for sublingual delivery of sildenafil citrate with enhanced …
Sildenafil citrate undergoes first-pass metabolism, resulting in poor oral bioavailability at 25–
41% of the administered dose. This study aimed to design and optimize fast-disintegrating …
41% of the administered dose. This study aimed to design and optimize fast-disintegrating …
Design-of-experiment approach to quantify the effect of nano-sized silica on tableting properties of microcrystalline cellulose to facilitate direct compression tableting of …
There are challenges to implementing high-speed direct compression tableting for poor flow,
low-density cohesive powder. Thus, excipients with adequate flowability and bulk density …
low-density cohesive powder. Thus, excipients with adequate flowability and bulk density …
Formulation and optimization of olanzapine-carboxylic acid cocrystals orodispersible tablets: In-vitro/In-vivo study
Oromucosal delivery of olanzapine (OLZ) is an optimal strategy to overcome low oral
bioavailability as well as improve medication adherence. However, its poor aqueous …
bioavailability as well as improve medication adherence. However, its poor aqueous …
Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized …
Designing a robust direct compression (DC) formulation for an active pharmaceutical
ingredient (API) with poor flow and compaction properties at a high API load is challenging …
ingredient (API) with poor flow and compaction properties at a high API load is challenging …
Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb.
Abstract Gambir (Uncaria gambir [Hunter] Roxb) is a plant that can effectively treat
hyperlipidemia. Its pharmacological effect is influenced by the high concentration of …
hyperlipidemia. Its pharmacological effect is influenced by the high concentration of …