To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense
reactions, many of which are shared with higher organisms. These reactions include the use …

Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …

Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to
ward off a variety of pathogens, some of which can cause disease in humans. To date, the …

We have identified 242 Anopheles gambiae genes from 18 gene families implicated in
innate immunity and have detected marked diversification relative to Drosophila …

Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite
for the establishment of a classical JAK-STAT signaling path. However, most vertebrate …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

The response of drosophila to bacterial and fungal infections involves two signaling
pathways, Toll and Imd, which both activate members of the transcription factor NF-κB family …

Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway
to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

Mosquito-borne diseases are responsible for significant human morbidity and mortality
throughout the world. Efforts to control mosquito-borne diseases have been impeded, in …