Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease

M Hoenigl, A Arastehfar, MC Arendrup… - Clinical Microbiology …, 2024‏ - journals.asm.org
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …

Fosmanogepix: a review of the first-in-class broad spectrum agent for the treatment of invasive fungal infections

KJ Shaw, AS Ibrahim - Journal of Fungi, 2020‏ - mdpi.com
Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …

Antifungal drugs: what brings the future?

R Van Daele, I Spriet, J Wauters, J Maertens… - Medical …, 2019‏ - academic.oup.com
The high burden and growing prevalence of invasive fungal infections (IFIs), the toxicity and
interactions associated with current antifungal drugs, as well as the increasing resistance …

[PDF][PDF] Hope on the horizon: novel fungal treatments in development

AM Rauseo, A Coler-Reilly, L Larson… - Open forum infectious …, 2020‏ - academic.oup.com
The treatment of invasive fungal infections remains challenging due to limitations in currently
available antifungal therapies including toxicity, interactions, restricted routes of …

Ten decadal advances in fungal biology leading towards human well-being

A Mapook, KD Hyde, K Hassan, BM Kemkuignou… - Fungal Diversity, 2022‏ - Springer
Fungi are an understudied resource possessing huge potential for develo** products that
can greatly improve human well-being. In the current paper, we highlight some important …

Aspergillus fumigatus and aspergillosis: from basics to clinics

A Arastehfar, A Carvalho, J Houbraken… - Studies in …, 2021‏ - ingentaconnect.com
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …

[HTML][HTML] Development and research progress of anti-drug resistant fungal drugs

X Cui, L Wang, Y Lue, C Yue - Journal of Infection and Public Health, 2022‏ - Elsevier
With the widespread use of immunosuppressive agents and the increase in patients with
severe infections, the incidence of fungal infections worldwide has increased year by year …

[HTML][HTML] Review of the novel investigational antifungal olorofim

NP Wiederhold - Journal of Fungi, 2020‏ - mdpi.com
The incidence of invasive fungal infections caused by molds and endemic fungi is
increasing. There is also concern regarding increased rates of reduced susceptibility or …

A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

KC Howard, EK Dennis, DS Watt… - Chemical Society …, 2020‏ - pubs.rsc.org
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

[HTML][HTML] Pharmacodynamics, mechanisms of action and resistance, and spectrum of activity of new antifungal agents

NP Wiederhold - Journal of Fungi, 2022‏ - mdpi.com
Several new antifungals are currently in late-stage development, including those with novel
pharmacodynamics/mechanisms of action that represent new antifungal classes …