Artificial intelligence for natural product drug discovery

MW Mullowney, KR Duncan, SS Elsayed… - Nature Reviews Drug …, 2023 - nature.com
Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

[HTML][HTML] Supplying plant natural products by yeast cell factories

D Romero-Suarez, JD Keasling, MK Jensen - Current Opinion in Green …, 2022 - Elsevier
Plant natural products have been used for centuries to treat human illnesses, as recreational
substances, and as flavoring and coloring agents in our food. Nowadays, commercial-scale …

The LOTUS initiative for open knowledge management in natural products research

A Rutz, M Sorokina, J Galgonek, D Mietchen… - elife, 2022 - elifesciences.org
Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape
knowledge management, analysis and interpretation of data in natural products research …

Lippia javanica leaf extract as an effective anti-corrosion agent against mild steel corrosion in 1 M HCl and its characterization by UHPLC/Q-TOF-MS spectroscopy and …

T Nesane, NE Madala, MM Kabanda… - Colloids and Surfaces A …, 2023 - Elsevier
A study was conducted to assess the anticorrosive potential of Lippia javanica leaf extract as
a mild steel corrosion inhibitor in 1 M HCl acidic media. The chemical compositions of the …

Exposomic biomonitoring of polyphenols by non-targeted analysis and suspect screening

I Oesterle, M Pristner, S Berger, M Wang… - Analytical …, 2023 - ACS Publications
Polyphenols, prevalent in plants and fungi, are investigated intensively in nutritional and
clinical settings because of their beneficial bioactive properties. Due to their complexity …

Next generation sequencing-aided screening, isolation, molecular identification, and antimicrobial potential for bacterial endophytes from the medicinal plant …

M Tlou, B Ndou, N Mabona, A Khwathisi… - Frontiers in …, 2024 - frontiersin.org
Elephantorrhiza elephantina, a wild plant in southern Africa, is utilized in traditional
medicine for various ailments, leading to its endangerment and listing on the Red List of …

[HTML][HTML] Assessing the stability of polyphenol content in red rooibos herbal tea using traditional methods and high-resolution mass spectrometry: Implications for …

R Mahamoud, DT Bowman, WE Ward, V Mangal - Food Chemistry, 2024 - Elsevier
Preclinical rodent models are used to examine the relationship between tea consumption
and bone health, where tea is available for rodents and typically replaced weekly. However …

MS-FINDER and SIRIUS for phenolic compound identification from high-resolution mass spectrometry data

LP Mallmann, AO Rios, E Rodrigues - Food Research International, 2023 - Elsevier
Abstract LC-HR-MS/MS is the predominant analytical technique in phenolic compound (PC)
research. However, the manual interpretation of mass spectra is a heavy nontrivial time …

[HTML][HTML] Temperature effects on growth, metabolome, lipidic profile and photosynthetic pigment content of Microglena antarctica (chlorophyceae): A comprehensive …

R Trentin, E Moschin, L Custódio, I Moro - Algal Research, 2024 - Elsevier
Antarctic microalgae have evolved a wide range of adaptations to survive at extreme
environmental conditions. This study aimed to explore the physiological and biochemical …

[HTML][HTML] A simple, cost-effective and optimized protocol for collecting root exudates from soil grown plants

S Döll, H Koller, NM van Dam - Rhizosphere, 2024 - Elsevier
Root exudates play a pivotal role in belowground interactions in both ecological and
agricultural contexts. The metabolic composition of exudates profoundly influences the …