[HTML][HTML] Applications of DNA tiling arrays for whole-genome analysis
DNA microarrays are a well-established technology for measuring gene expression levels.
Microarrays designed for this purpose use relatively few probes for each gene and are …
Microarrays designed for this purpose use relatively few probes for each gene and are …
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
JR Mayers, ME Torrence, LV Danai… - Science, 2016 - science.org
Tumor genetics guides patient selection for many new therapies, and cell culture studies
have demonstrated that specific mutations can promote metabolic phenotypes. However …
have demonstrated that specific mutations can promote metabolic phenotypes. However …
[HTML][HTML] MicroRNA regulation of cell lineages in mouse and human embryonic stem cells
Cell fate decisions of pluripotent embryonic stem (ES) cells are dictated by activation and
repression of lineage-specific genes. Numerous signaling and transcriptional networks …
repression of lineage-specific genes. Numerous signaling and transcriptional networks …
Heterogeneity of tumor-induced gene expression changes in the human metabolic network
Reprogramming of cellular metabolism is an emerging hallmark of neoplastic
transformation. However, it is not known how the expression of metabolic genes in tumors …
transformation. However, it is not known how the expression of metabolic genes in tumors …
LRRK2 is involved in the IFN-γ response and host response to pathogens
A Gardet, Y Benita, C Li, BE Sands… - The Journal of …, 2010 - journals.aai.org
LRRK2 was previously identified as a defective gene in Parkinson's disease, and it is also
located in a risk region for Crohn's disease. In this study, we aim to determine whether …
located in a risk region for Crohn's disease. In this study, we aim to determine whether …
Fusion gene–negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma
D Williamson, E Missiaglia, A de Reynies… - Journal of Clinical …, 2010 - ascopubs.org
Purpose To determine whether the clinical and molecular biologic characteristics of the
alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) subtypes …
alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) subtypes …
Invasion by P. falciparum Merozoites Suggests a Hierarchy of Molecular Interactions
Central to the pathology of malaria disease are the repeated cycles of parasite invasion and
destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species …
destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species …
PyCDT: A Python toolkit for modeling point defects in semiconductors and insulators
Point defects have a strong impact on the performance of semiconductor and insulator
materials used in technological applications, spanning microelectronics to energy …
materials used in technological applications, spanning microelectronics to energy …
Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer
ED Wiklund, JB Bramsen, T Hulf… - … journal of cancer, 2011 - Wiley Online Library
MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR‐
200 family (miR‐200a,‐200b,‐200c,‐141 and‐429) and miR‐205 are frequently silenced in …
200 family (miR‐200a,‐200b,‐200c,‐141 and‐429) and miR‐205 are frequently silenced in …
Tight junction–associated MARVEL proteins MarvelD3, tricellulin, and occludin have distinct but overlap** functions
In vitro studies have demonstrated that occludin and tricellulin are important for tight junction
barrier function, but in vivo data suggest that loss of these proteins can be overcome. The …
barrier function, but in vivo data suggest that loss of these proteins can be overcome. The …