This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Transplantation of allogeneic pancreatic donor islets has successfully been performed in
selected patients with difficult-to-control insulin-dependent diabetes and impaired …

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is
characterized by dysfunction of insulin-producing pancreatic islet β cells1, 2. T2D genome …

Background Diabetes always involves variable degrees of β-cell demise and malfunction
leading to insufficient insulin secretion. Besides clinical investigations, many research …

Islet transplantation represents an effective treatment for patients with type 1 diabetes
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …

Approximately 33.6% of nondiabetic solid organ transplant recipients who received
tacrolimus developed hyperglycemia. Whether the tacrolimus-induced gut microbiota is …

Macroautophagy/autophagy or mitophagy plays crucial roles in the maintenance of
pancreatic β-cell function. PPP3/calcineurin can modulate the activity of TFEB, a master …

Type 1 diabetes mellitus (T1DM) is an autoimmune condition that results in the destruction of
insulin-secreting β cells of the islets of Langerhans. Allogeneic islet transplantation could be …

As a newly emerging organ transplantation technique, islet transplantation has shown the
advantages of minimal trauma and high safety since it was first carried out. The proposal of …