Combination therapy against cancer has gained increasing attention because it can help to
target multiple pathways to tackle oncologic progression and improve the limited antitumor …

Osteosarcoma, a rare primary bone cancer, presents diverse molecular aberrations that
underscore its complexity. Despite the persistent endeavors by researchers, the limited …

Ferroptosis is characterized by iron accumulation and lipid peroxidation. However, a clinical
dose of Fe3O4 nanoparticles could not cause effective ferroptosis in tumors, and the …

Metabolic reprogramming is an adaptive response of tumour cells under hypoxia and low
nutrition conditions. There is increasing evidence that glucose metabolism reprogramming …

Background Osteosarcoma is highly malignant. The migration, invasion, and
chemoresistance contribute to poor prognosis of osteosarcoma. Research reported that …

Telomere repeat binding factor 2 (TRF2), a critical element of the shelterin complex, plays a
vital role in the maintenance of genome integrity. TRF2 overexpression is found in a wide …

In the last decade, researchers have paid much attention to the role of noncoding RNA
molecules in human diseases. Among the most important of these molecules are LncRNAs …

Chemoresistance remains the main obstacle limiting the treatment of osteosarcoma,
seriously affecting the prognosis of adolescent patients with osteosarcoma. Recently, long …

Cancer chemotherapy is still a serious challenge. Chemo-resistance and destructive side
effects of chemotherapy drugs are the most critical limitations of chemotherapy. Chemo …

Bone sarcomas are rare heterogeneous tumors that affect patients of all ages including
children, adolescent young adults, and older adults. They include many aggressive …