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[HTML][HTML] Radioresistance in Glioblastoma and the Development of Radiosensitizers
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …
identified but have not yet resulted in development of effective radiosensitizer that can …
Prognostic and therapeutic roles of the insulin growth factor system in glioblastoma
Glioblastoma multiforme (GBM) is the most common primary brain malignancy and is often
resistant to conventional treatments due to its extensive cellular heterogeneity. Thus, the …
resistant to conventional treatments due to its extensive cellular heterogeneity. Thus, the …
IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are often linked to drug
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …
resistance. Here, we found that coculture with CAFs or culture in CAF-conditioned medium …
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma
Glioblastoma (GBM) is the most common and fatal primary tumor of the central nervous
system (CNS) and current treatments have limited success. Chemokine signaling regulates …
system (CNS) and current treatments have limited success. Chemokine signaling regulates …
[HTML][HTML] Novel regulators of the IGF system in cancer
The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes
cognate ligands, membrane receptors, ligand binding proteins and functional downstream …
cognate ligands, membrane receptors, ligand binding proteins and functional downstream …
Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer
A Gambelli, A Nespolo… - EMBO Molecular …, 2024 - embopress.org
Abstract Platinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic
disease, disseminating in the abdomen and pelvis. Very few options are available for PT …
disease, disseminating in the abdomen and pelvis. Very few options are available for PT …
The roles of insulin-like growth factor binding protein family in development and diseases
F Song, XX Zhou, Y Hu, G Li, Y Wang - Advances in Therapy, 2021 - Springer
The insulin-like growth factor (IGF) system comprises ligands of IGF-I/II, IGF receptors
(IGFR), IGF binding proteins (IGFBPs), and IGFBP hydrolases. The IGF system plays multiple …
(IGFR), IGF binding proteins (IGFBPs), and IGFBP hydrolases. The IGF system plays multiple …
Targeting IGF2 to reprogram the tumor microenvironment for enhanced viro-immunotherapy
Background The FDA approval of oncolytic herpes simplex-1 virus (oHSV) therapy
underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this …
underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this …
Tracing the origins of glioblastoma by investigating the role of gliogenic and related neurogenic genes/signaling pathways in GBM development: a systematic review
O Shafi, G Siddiqui - World Journal of Surgical Oncology, 2022 - Springer
Background Glioblastoma is one of the most aggressive tumors. The etiology and the factors
determining its onset are not yet entirely known. This study investigates the origins of GBM …
determining its onset are not yet entirely known. This study investigates the origins of GBM …
TMZ regulates GBM stemness via MMP14‐DLL4‐Notch3 pathway
Glioblastoma (GBM) is one of the most aggressive primary brain tumors with frequent
recurrences following the standard methods of treatment—temozolomide (TMZ), ionizing …
recurrences following the standard methods of treatment—temozolomide (TMZ), ionizing …