Effect of the Rho-Kinase/ROCK signaling pathway on cytoskeleton components

G Guan, RD Cannon, DE Coates, L Mei - Genes, 2023 - mdpi.com
The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

Erectile dysfunction: treatments, advances and new therapeutic strategies

A Argiolas, FM Argiolas, G Argiolas, MR Melis - Brain sciences, 2023 - mdpi.com
Erectile dysfunction (ED) is the inability to get and maintain an adequate penile erection for
satisfactory sexual intercourse. Due to its negative impacts on men's life quality and increase …

Management of priapism: an update for clinicians

HR Levey, RL Segal… - Therapeutic advances in …, 2014 - journals.sagepub.com
Priapism is a prolonged erection that persists beyond or is unrelated to sexual stimulation. It
is associated with significant morbidity: psychological, socioeconomic, and physical …

Molecular pathogenesis and treatment of cavernous nerve injury-induced erectile dysfunction: a narrative review

G Song, P Hu, J Song, J Liu, Y Ruan - Frontiers in Physiology, 2022 - frontiersin.org
Introduction: Erectile dysfunction (ED) is a common complication after radical prostatectomy
(RP), and it seriously affects the quality of life in patients and their partners. The primary …

Pathophysiology of erectile dysfunction

H Matsui, NA Sopko, JL Hannan… - Current drug …, 2015 - ingentaconnect.com
Erectile dysfunction (ED) is a major health problem as the population ages. Basic science
research for the last two decades has expanded the knowledge on ED and identified several …

Understanding and targeting the Rho kinase pathway in erectile dysfunction

NA Sopko, JL Hannan, TJ Bivalacqua - Nature Reviews Urology, 2014 - nature.com
Erectile dysfunction (ED) is a common disorder that affects a quarter of US men, and has
many causes, including endothelial impairment, low testosterone levels, prior surgical …

Translational perspective on the role of testosterone in sexual function and dysfunction

CA Podlasek, J Mulhall, K Davies… - The journal of sexual …, 2016 - academic.oup.com
Introduction The biological importance of testosterone is generally accepted by the medical
community; however, controversy focuses on its relevance to sexual function and the sexual …

Neuroprotective and nerve regenerative approaches for treatment of erectile dysfunction after cavernous nerve injury

JD Campbell, AL Burnett - International Journal of Molecular Sciences, 2017 - mdpi.com
Erectile dysfunction (ED) is a significant cause of reduced quality of life in men and their
partners. Cavernous nerve injury (CNI) during pelvic surgery results in ED in greater than …

Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve‐injured rats

JL Hannan, O Kutlu, BL Stopak, X Liu… - The Journal of …, 2014 - academic.oup.com
Introduction Bilateral cavernous nerve injury (BCNI) causes profound penile changes such
as apoptosis and fibrosis leading to erectile dysfunction (ED). Histone deacetylase (HDAC) …

Erectile hydraulics: maximizing inflow while minimizing outflow

DR Meldrum, AL Burnett, G Dorey… - The journal of sexual …, 2014 - academic.oup.com
Introduction Penile rigidity depends on maximizing inflow while minimizing outflow. Aim The
aim of this review is to describe the principal factors and mechanisms involved. Main …