Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

In pragmatic trials, participants are broadly representative of people who will receive a
treatment or diagnostic strategy, and the outcomes affect day-to-day care. The authors …

The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Executive summary A concerted effort to tackle the global health problem posed by traumatic
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …

Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Traumatic brain injury (TBI) is the most common cause of death and disability in those aged
under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income …

Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

Context Lung-protective mechanical ventilation with the use of lower tidal volumes has been
found to improve outcomes of patients with acute respiratory distress syndrome (ARDS). It …

Importance Optimal health care delivery, both now and in the future, requires a continuous
loop of knowledge generation, dissemination, and uptake on how best to provide care, not …

Background Each year, worldwide, about 3 million people die as a result of trauma, many
after reaching hospital. Among trauma patients who do survive to reach hospital, bleeding is …