Neurodevelopmental and functional outcomes following in utero exposure to antiseizure medication: a systematic review

E Honybun, E Cockle, CB Malpas, TJ O'Brien… - Neurology, 2024 - AAN Enterprises
Background and Objectives To undertake a systematic review of the available literature to
examine the relationship between prenatal antiseizure medication (ASM) exposure and …

Management of epilepsy during pregnancy and lactation

OA Hope, KMJ Harris - bmj, 2023 - bmj.com
Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent
seizures. Antiseizure medications (ASMs) are the mainstay of treatment, but many …

Prenatal exposure to antiseizure medication and incidence of childhood-and adolescence-onset psychiatric disorders

JW Dreier, MH Bjørk, S Alvestad, M Gissler… - JAMA …, 2023 - jamanetwork.com
Importance Prenatal antiseizure medication (ASM) exposure has been associated with
adverse early neurodevelopment, but associations with a wider range of psychiatric end …

Antiseizure medication concentrations during pregnancy: results from the maternal outcomes and neurodevelopmental effects of antiepileptic drugs (MONEAD) study

PB Pennell, A Karanam, KJ Meador, E Gerard… - JAMA …, 2022 - jamanetwork.com
Importance During pregnancy in women with epilepsy, lower blood concentrations of
antiseizure medications can have adverse clinical consequences. Objective To characterize …

Cognitive outcomes at age 3 years in children with fetal exposure to antiseizure medications (MONEAD study) in the USA: a prospective, observational cohort study

KJ Meador, MJ Cohen, DW Loring… - The Lancet …, 2023 - thelancet.com
Background The neurodevelopmental effects of fetal exposure to most antiseizure
medications are unclear. We aimed to investigate the effects of fetal exposure to commonly …

Behavioral outcomes and neurodevelopmental disorders among children of women with epilepsy

MJ Cohen, KJ Meador, DW Loring, AG Matthews… - JAMA …, 2024 - jamanetwork.com
Importance The association of fetal exposure to antiseizure medications (ASMs) with
outcomes in childhood are not well delineated. Objective To examine the association of fetal …

Trends in antiseizure medication prescription patterns among all adults, women, and older adults with epilepsy: A German longitudinal analysis from 2008 to 2020

M Hochbaum, R Kienitz, F Rosenow, J Schulz… - Epilepsy & Behavior, 2022 - Elsevier
Introduction The prescription patterns of antiseizure medication (ASM) are subject to new
scientific evidence and sociodemographic and practical aspects. This study analyzed trends …

Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes

P Madley-Dowd, VH Ahlqvist, H Forbes, JE Rast… - Nature …, 2024 - nature.com
The teratogenic potential of valproate in pregnancy is well established; however, evidence
regarding the long-term safety of other antiseizure medications (ASMs) during pregnancy …

Perinatal mental health: advances and opportunities

ZN Stowe - American Journal of Psychiatry, 2023 - Am Psychiatric Assoc
The past 60 years have seen increasing awareness and advancement in the area of
perinatal mental health. The initial formation of the International Society for Psychosomatic …

Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability

R Feleke, D Jazayeri, M Abouzeid, KL Powell… - Brain, 2022 - academic.oup.com
Prenatal exposure to the anti-seizure medication sodium valproate (VPA) is associated with
an increased risk of adverse postnatal neurodevelopmental outcomes, including lowered …