Molecular characterization of membrane steroid receptors in hormone-sensitive cancers

M Masi, M Racchi, C Travelli, E Corsini, E Buoso - Cells, 2021 - mdpi.com
Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Unveiling the immune microenvironment's role in breast cancer: A glimpse into promising frontiers

A Kotsifaki, N Alevizopoulos, V Dimopoulou… - International Journal of …, 2023 - mdpi.com
Breast cancer (BC), one of the most widespread and devastating diseases affecting women
worldwide, presents a significant public health challenge. This review explores the emerging …

Skewing cPLA2α activity toward oxoeicosanoid production promotes neutrophil N2 polarization, wound healing, and the response to sepsis

KD Maus, DJ Stephenson, HP Macknight, NT Vu… - Science …, 2023 - science.org
Uncontrolled inflammation is linked to poor outcomes in sepsis and wound healing, both of
which proceed through distinct inflammatory and resolution phases. Eicosanoids are a class …

RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin

R Tian, J Tian, X Zuo, S Ren, H Zhang, H Liu… - Cell Death & …, 2023 - nature.com
The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with
multifunctional and multifaceted properties. By mediating protein-protein interactions …

Anabolic steroids-driven regulation of porcine ovarian putative stem cells favors the onset of their neoplastic transformation

G Gorczyca, K Wartalski, J Wiater, M Samiec… - International Journal of …, 2021 - mdpi.com
Nandrolone (Ndn) and boldenone (Bdn), the synthetic testosterone analogues with strong
anabolic effects, despite being recognized as potentially carcinogenic compounds, are …

E2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression

C Ashok, N Ahuja, S Natua, J Mishra, A Samaiya… - Oncogenesis, 2021 - nature.com
Epithelial splicing regulatory protein 1 (ESRP1) is an RNA binding protein that governs the
alternative splicing events related to epithelial phenotypes. ESRP1 contributes significantly …

Effects of endocrine active contaminating pesticides on RACK1 expression and immunological consequences in THP-1 cells

A Maddalon, M Masi, M Iulini, P Linciano… - Environmental …, 2022 - Elsevier
We have previously demonstrated that RACK1, which expression is under steroid hormone
control, plays an important role in the activation of immune cells and its expression can be …

Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation

M Masi, A Maddalon, M Iulini, P Linciano, V Galbiati… - Toxicology, 2022 - Elsevier
The existence of a complex hormonal balance among glucocorticoids, androgens and
estrogens involved in the regulation of Receptor for Activated C Kinase 1 (RACK1) …

Effects of bisphenols on RACK1 expression and their immunological implications in THP-1 cells

E Buoso, M Kenda, M Masi, P Linciano… - Frontiers in …, 2021 - frontiersin.org
Receptor for activated C kinase 1 (RACK1) has an important role in immune activation, and
is regulated through a balance between glucocorticoid and androgen levels. We have …

Multi-omics analyses provide novel biological insights to distinguish lobular ductal types of invasive breast cancers

A Sivadas, VC Kok, KL Ng - Breast cancer research and treatment, 2022 - Springer
Background Invasive lobular carcinoma (ILC) treatment is similar to invasive ductal
carcinoma (IDC; now invasive carcinoma-no special type, IBC-NST), based on its intrinsic …