The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

A scalable continuous manufacturing process for the synthesis and crystallization of form III
carbamazepine (CBZ) from iminostilbene (ISB) has been established. A high-yielding …

Using process modeling to understand process dynamics and potentially explore the design
space of a crystallization process is difficult because of its complex nature with many factors …

A common objective of various crystallization procedures is to produce polymorphic pure
crystals that have a narrow size distribution and a specific average crystal size. A cooling …

Develo** a crystallization model that accurately predicts crystal growth and nucleation has
been an important topic in the pharmaceutical industry for the past few decades. Particularly …

The solution-mediated polymorphic transformation (SMPT) of l-glutamic acid is modeled
using the method of moments (MoM) with the addition of a dissolution term to account for the …

A generic modeling framework for batch cooling crystallization processes has been
developed to understand the crystallization process from operational and modeling point of …

As an important means of solid-liquid separation, the crystallization from solution is a key
technology for achieving high value of pharmaceutical products. The precise control of …

The study of nano-and submicron Brownian particle-laden turbulent flow has wide industrial
applicability and hence has received much attention. The purpose of the present paper is to …

This work presents a comprehensive study on the application of PAT tools to study, monitor
and control polymorphism during batch cooling crystallization process. For the first time, the …