Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis

SG Barreto, A Habtezion, A Gukovskaya, A Lugea… - Gut, 2021 - gut.bmj.com
Acute pancreatitis (AP), an acute inflammatory disorder of the exocrine pancreas, is one of
the most common gastrointestinal diseases encountered in emergency departments with no …

Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis

ER Bálint, G Fűr, L Kiss, DI Németh, A Soós, P Hegyi… - Scientific Reports, 2020 - nature.com
The main causes of acute pancreatitis (AP) are biliary disease, alcohol consumption,
hypertriglyceridaemia (HTG) and endoscopic retrograde cholangiopancreatography …

[HTML][HTML] Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis

J Maléth, A Balázs, P Pallagi, Z Balla, B Kui, M Katona… - Gastroenterology, 2015 - Elsevier
Background & Aims Excessive consumption of ethanol is one of the most common causes of
acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis …

Role of antioxidants and oxidative stress in the evolution of acute pancreatitis

V Pădureanu, DN Florescu… - Experimental and …, 2022 - spandidos-publications.com
Acute pancreatitis (AP) is a severe disease with a high prevalence and 3 to 15% mortality
worldwide, which can represent an important challenge for the physician. Oxidative stress …

[HTML][HTML] Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives

P Pallagi, T Madácsy, Á Varga, J Maléth - International Journal of …, 2020 - mdpi.com
Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …

Pancreatitis in dogs and cats: definitions and pathophysiology

P Watson - Journal of small animal practice, 2015 - Wiley Online Library
Pancreatitis, or inflammation of the pancreas, is commonly seen in dogs and cats and
presents a spectrum of disease severities from acute to chronic and mild to severe. It is …

The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis

L Kiss, G Fűr, P Mátrai, P Hegyi, E Ivány, IM Cazacu… - Scientific reports, 2018 - nature.com
Elevated serum triglyceride concentration (seTG,> 1.7 mM or> 150 mg/dL) or in other words
hypertriglyceridemia (HTG) is common in the populations of developed countries. This …

The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology

P Hegyi, OH Petersen - Reviews of Physiology, Biochemistry and …, 2013 - Springer
There are many reviews of pancreatic acinar cell function and also of pancreatic duct
function, but there is an almost total absence of synthetic reviews bringing the integrated …

The physiology and pathophysiology of pancreatic ductal secretion: the background for clinicians

P Pallagi, P Hegyi, Z Rakonczay Jr - Pancreas, 2015 - journals.lww.com
The human exocrine pancreas consists of 2 main cell types: acinar and ductal cells. These
exocrine cells interact closely to contribute to the secretion of pancreatic juice. The most …

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

T Madácsy, P Pallagi, J Maleth - Frontiers in Physiology, 2018 - frontiersin.org
Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …