Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Abstract We describe Strelka2 (https://github. com/Illumina/strelka), an open-source small-
variant-calling method for research and clinical germline and somatic sequencing …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the develo** child, and highlight the need for molecularly targeted …

Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the
transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands …

Explosive advances in next‐generation sequencer (NGS) and computational analyses have
enabled exploration of somatic protein‐altered mutations in most cancer types, with coding …

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

Abstract The 'Individualized Therapy for Relapsed Malignancies in Childhood'(INFORM)
precision medicine study is a nationwide German program for children with high-risk …

Many disciplines, from human genetics and oncology to plant breeding, microbiology and
virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes …