The emergence, genomic diversity and global spread of SARS-CoV-2

J Li, S Lai, GF Gao, W Shi - Nature, 2021 - nature.com
Since the first cases of COVID-19 were documented in Wuhan, China in 2019, the world has
witnessed a devastating global pandemic, with more than 238 million cases, nearly 5 million …

[HTML][HTML] Review of COVID-19 testing and diagnostic methods

O Filchakova, D Dossym, A Ilyas, T Kuanysheva… - Talanta, 2022 - Elsevier
More than six billion tests for COVID-19 has been already performed in the world. The
testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and …

Network pharmacology approach for medicinal plants: review and assessment

F Noor, M Tahir ul Qamar, UA Ashfaq, A Albutti… - Pharmaceuticals, 2022 - mdpi.com
Natural products have played a critical role in medicine due to their ability to bind and
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …

COVID-19: a global challenge with old history, epidemiology and progress so far

M Khan, SF Adil, HZ Alkhathlan, MN Tahir, S Saif… - Molecules, 2020 - mdpi.com
Humans have witnessed three deadly pandemics so far in the twenty-first century which are
associated with novel coronaviruses: SARS, Middle East respiratory syndrome (MERS), and …

Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a

S Lu, X Tong, Y Han, K Zhang, Y Zhang… - Nature biomedical …, 2022 - nature.com
CRISPR-based assays for the detection of nucleic acids are highly specific, yet they are not
fast, sensitive or easy to use. Here we report a one-step fluorescence assay for the detection …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R **ang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

Aging in COVID-19: Vulnerability, immunity and intervention

Y Chen, SL Klein, BT Garibaldi, H Li, C Wu… - Ageing research …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …

From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses

Z Zhu, X Lian, X Su, W Wu, GA Marraro, Y Zeng - Respiratory research, 2020 - Springer
Within two decades, there have emerged three highly pathogenic and deadly human
coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden …

Distinct conformational states of SARS-CoV-2 spike protein

Y Cai, J Zhang, T **ao, H Peng, SM Sterling… - Science, 2020 - science.org
Intervention strategies are urgently needed to control the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion …