Bioinspired nanotopographical design of drug delivery systems

JA Finbloom, C Huynh, X Huang… - Nature Reviews …, 2023‏ - nature.com
Effective drug delivery is important in the treatment of various biomedical conditions, ranging
from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can …

Nanotechnology based drug delivery systems: Does shape really matter?

S Shah, P Famta, D Bagasariya, K Charankumar… - International Journal of …, 2022‏ - Elsevier
As of today, the era of nanomedicine has brought numerous breakthroughs and overcome
challenges in the treatment of various disorders. Various factors like size, charge and …

[HTML][HTML] Recent advances in the microfluidic generation of shape-controllable hydrogel microparticles and their applications

Y Liu, Z Chen, J Xu - Green Chemical Engineering, 2024‏ - Elsevier
Hydrogel microparticles, generally accepted as significant green materials, have been
widely used in chemical, biological, and biomedical fields owing to their excellent …

Close-to-native bone repair via tissue-engineered endochondral ossification approaches

S Nadine, IJ Fernandes, CR Correia, JF Mano - IScience, 2022‏ - cell.com
In order to solve the clinical challenges related to bone grafting, several tissue engineering
(TE) strategies have been proposed to repair critical-sized defects. Generally, the classical …

Self‐Assembly of Platelet Lysates Proteins into Microparticles by Unnatural Disulfide Bonds for Bottom‐Up Tissue Engineering

MC Gomes, AR Pinho, C Custódio… - Advanced …, 2023‏ - Wiley Online Library
There is a demand to design microparticles holding surface topography while presenting
inherent bioactive cues for applications in the biomedical and biotechnological fields. Using …

MicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction

Z Li, J Tang, L Zhou, J Mao, W Wang, Z Huang… - ACS …, 2025‏ - ACS Publications
The extracellular matrix (ECM) stores signaling molecules and facilitates mechanical and
biochemical signaling in cells. However, the influence of biomimetic “rejuvenation” ECM …

Preparation of assemblable chondral and subchondral bone microtissues for osteochondral tissue engineering

P **a, S Yan, G Li, J Yin - ACS Applied Materials & Interfaces, 2022‏ - ACS Publications
Microtissues exhibit great advantages in injecting with minimum invasiveness, mimicking
natural tissues, and promoting tissue regeneration. However, very few studies have focused …

Microfluidic engineering of crater–terrain hydrogel microparticles: toward novel cell carriers

Y Zheng, Z Wu, Y Hou, N Li, Q Zhang… - ACS Applied Materials & …, 2023‏ - ACS Publications
Fabrication and application of novel anisotropic microparticles are of wide interest. Herein, a
new method for producing novel crater–terrain hydrogel microparticles is presented using a …

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone microenvironment engineering

D Jesus, AR Pinho, MC Gomes, CS Oliveira, JF Mano - Soft Matter, 2022‏ - pubs.rsc.org
Bone presents an intrinsic ability for self-regeneration and repair, however critical defects
and large fractures require invasive and time-consuming clinical interventions. As an …