Regenerative medicine is a new and promising mode of therapy for patients who have
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show considerable
promise for regenerating injured hearts, and we therefore tested their capacity to stably …

Neglected for years, astrocytes are now recognized to fulfill and support many, if not all,
homeostatic functions of the healthy central nervous system (CNS). During …

Myocardial injury results in a loss of contractile tissue mass that, in the absence of efficient
regeneration, is essentially irreversible. Transplantation of human pluripotent stem cell …

Abstract In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and
spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore …

The scarcity of donor organs may be addressed in the future by using pigs to grow
humanized organs with lower potential for immunological rejection after transplantation in …

OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic
Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific …

Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) offer an
unprecedented opportunity to remuscularize infarcted human hearts. However, studies have …

The natural ability of stem cells to self-organize into functional tissue has been harnessed for
the production of functional human intestinal organoids. Although dynamic mechanical …

Abstract Three-dimensional (3D) organoid models derived from human pluripotent stem
cells provide a platform for studying human development and understanding disease …