Sleep plays a vital role in brain function and systemic physiology across many body
systems. Problems with sleep are widely prevalent and include deficits in quantity and …

Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in
the vast majority of species on Earth. The biological clockwork that regulates these rhythms …

There has been a recent surge of interest in the unique low molecular weight dietary
thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Abstract Study Objectives: Obstructive sleep apnea (OSA) is a common sleep disorder. The,
literature lacks studies examining sleep, cognition, and Alzheimer's Disease (AD) …

Slow-wave sleep (SWS) modulation in rodent models of Alzheimer's disease alters
extracellular amyloid burden. In Parkinson's disease (PD), SWS appears to be closely linked …

Sleep complaints can be both common and complex in the older patient. Their consideration
is an important aspect of holistic care, and may have an impact on quality of life, mortality …