Aldosterone and aldosterone synthase inhibitors in cardiorenal disease
Modulation of the renin-angiotensin-aldosterone system is a foundation of therapy for
cardiovascular and kidney diseases. Excess aldosterone plays an important role in …
cardiovascular and kidney diseases. Excess aldosterone plays an important role in …
Clinical utility of osilodrostat in Cushing's Disease: review of currently available literature
M Perosevic, NA Tritos - Drug Design, Development and Therapy, 2023 - Taylor & Francis
Cushing's disease (CD) is caused by endogenous hypercortisolism as a result of
adrenocorticotropin (ACTH) secretion from a pituitary tumor. The condition is associated with …
adrenocorticotropin (ACTH) secretion from a pituitary tumor. The condition is associated with …
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin
Aldosterone is the major mineralocorticoid in the human body controlling blood pressure
and salt homeostasis. Overproduction of aldosterone leads to primary aldosteronism, which …
and salt homeostasis. Overproduction of aldosterone leads to primary aldosteronism, which …
Adrenodoxin allosterically alters human cytochrome P450 11B enzymes to accelerate substrate binding and decelerate release
Two human mitochondrial membrane CYP11B enzymes play a pivotal role in
steroidogenesis. CYP11B1 generates the major glucocorticoid cortisol, while CYP11B2 …
steroidogenesis. CYP11B1 generates the major glucocorticoid cortisol, while CYP11B2 …
Taming resistant hypertension: The promise of novel pharmacologic approaches and renal denervation
O Azzam, SH Nejad, R Carnagarin… - British Journal of …, 2024 - Wiley Online Library
Resistant hypertension is associated with an exceedingly high cardiovascular risk and there
remains an unmet therapeutic need driven by pathophysiologic pathways unaddressed by …
remains an unmet therapeutic need driven by pathophysiologic pathways unaddressed by …
Evaluating the role of aldosterone synthesis on adrenal cell fate
Hypertension affects one-third of the adult population worldwide, with primary aldosteronism
(PA) accounting for at least 5-10% of these cases. The aldosterone synthase enzyme …
(PA) accounting for at least 5-10% of these cases. The aldosterone synthase enzyme …
Redox partner adrenodoxin alters cytochrome P450 11B1 ligand binding and inhibition
Abstract Human cytochrome P450 11B1 (CYP11B1) generation of the major glucocorticoid
cortisol requires two electrons delivered sequentially by the iron‑sulfur protein adrenodoxin …
cortisol requires two electrons delivered sequentially by the iron‑sulfur protein adrenodoxin …
Emerging Trends in Small Molecule Inhibitors Targeting Aldosterone Synthase: A New Paradigm in Cardiovascular Disease Treatment
C Guo, G Zhang, C Wu, Y Lei, Y Wang… - European Journal of …, 2024 - Elsevier
Abstract Aldosterone synthase (CYP11B2) is the rate-limiting enzyme in aldosterone
production. In recent years, CYP11B2 has become an appealing target for treating …
production. In recent years, CYP11B2 has become an appealing target for treating …
Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase
A Tinivella, M Banchi, G Gambacorta… - ACS pharmacology & …, 2023 - ACS Publications
Estrogen deficiency derived from inhibition of estrogen biosynthesis is a typical condition of
postmenopausal women and breast cancer (BCs) patients undergoing antihormone therapy …
postmenopausal women and breast cancer (BCs) patients undergoing antihormone therapy …
Visible-light-driven aldehyde ammoxidation to nitrile via• O2–and• NHx radicals generation over Ni (OH) 2/TiO2 pn heterojunctions
Y Zhou, J Zhao, H Guo, C Wang - Journal of Catalysis, 2025 - Elsevier
Aldehydes ammoxidation is a green and promising route for selective synthesis of nitrile, but
develo** low-cost and efficient catalytic system under mild condition remains a challenge …
develo** low-cost and efficient catalytic system under mild condition remains a challenge …