Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …
Bioengineering approaches for the advanced organoid research
Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …
derived organoids that recapitulate the structural and functional characteristics of native …
[HTML][HTML] Comparative analysis and refinement of human PSC-derived kidney organoid differentiation with single-cell transcriptomics
Kidney organoids derived from human pluripotent stem cells have great utility for
investigating organogenesis and disease mechanisms and, potentially, as a replacement …
investigating organogenesis and disease mechanisms and, potentially, as a replacement …
Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro
INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …
extraembryonic tissues and a highly coordinated partnership between them. This close …
Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine
H Xu, Y Jiao, S Qin, W Zhao, Q Chu, K Wu - Experimental hematology & …, 2018 - Springer
Organoid technology bridges the gap between conventional two-dimensional cell line
culture and in vivo models. The near-physiological technology can virtually recapitulates …
culture and in vivo models. The near-physiological technology can virtually recapitulates …
[HTML][HTML] Human pluripotent stem cell-derived kidney organoids with improved collecting duct maturation and injury modeling
Maximizing the potential of human kidney organoids for drug testing and regenerative
medicine and to model development and disease requires addressing cell immaturity, the …
medicine and to model development and disease requires addressing cell immaturity, the …
Kidney-based in vitro models for drug-induced toxicity testing
The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells
A variety of protocols have been developed that demonstrate the capability to differentiate
human pluripotent stem cells (hPSCs) into kidney structures. Our goal was to develop a high …
human pluripotent stem cells (hPSCs) into kidney structures. Our goal was to develop a high …