This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

The psychedelic effects of some plants and fungi have been known and deliberately
exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Psychedelic drugs are increasingly being incorporated into therapeutic contexts for the
purposes of promoting mental health. However, they can also induce adverse reactions in …

Research into the basic effects and therapeutic applications of psychedelic drugs has grown
considerably in recent years. Yet, pressing questions remain regarding the substances' …

Objective To determine the efficacy of psilocybin as an antidepressant compared with
placebo or non-psychoactive drugs. Design Systematic review and meta-analysis. Data …

Approximately 30% of people treated for a major depressive episode will not achieve
remission after two or more treatment trials of first-line antidepressants and are considered …

Can the use of psychedelic drugs induce lasting changes in metaphysical beliefs? While it is
popularly believed that they can, this question has never been formally tested. Here we …

Background: Psychedelic use is anecdotally associated with belief changes, although few
studies have tested these claims. Aim: Characterize a broad range of psychedelic …

The administration of classic psychedelics has been associated with well-being and mental
health benefits as well as risks and adverse events. The acute subjective effects of …