ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that
affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of …

Piezo proteins are mechanically activated ion channels, which are required for
mechanosensing functions in a variety of cell types. While we and others have previously …

Osteoarthritis (OA) is a common degenerative joint disease, mainly presented by the
deterioration of articular cartilage. Amounts of data demonstrated this deterioration is …

To date, several molecules have been found to facilitate iron influx, while the types of iron
influx channels remain to be elucidated. Here, Piezo1 channel was identified as a key iron …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Knee osteoarthritis (KOA) is a common chronic disease in orthopedics, which brings great
pain to patients' life and spirit. Therefore, it is necessary to elucidate the pathogenesis of …

The cation channel Piezo1, a crucial mechanotransducer found in various organs and
tissues, has gained considerable attention as a therapeutic target in recent years. Following …