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FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat
Y Dong, R Tu, H Liu, G Qing - Signal transduction and targeted therapy, 2020 - nature.com
Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …
proliferation. As such, most human cancers differ from normal counterpart tissues by a …
PTEN: tumor suppressor and metabolic regulator
Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …
The role of sirtuins in antioxidant and redox signaling
Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …
[HTML][HTML] Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis
S Zhong, W Chen, B Wang, C Gao, X Liu, Y Song, H Qi… - Redox biology, 2023 - Elsevier
Cancer cells and ischemic diseases exhibit unique metabolic responses and adaptations to
energy stress. Forkhead box O 3a (FoxO3a) is a transcription factor that plays an important …
energy stress. Forkhead box O 3a (FoxO3a) is a transcription factor that plays an important …
MYC, metabolism, and cancer
The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
[HTML][HTML] Sirt1 and the mitochondria
BL Tang - Molecules and cells, 2016 - Elsevier
Sirt1 is the most prominent and extensively studied member of sirtuins, the family of
mammalian class III histone deacetylases heavily implicated in health span and longevity …
mammalian class III histone deacetylases heavily implicated in health span and longevity …
[HTML][HTML] Redox regulation of FoxO transcription factors
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …
the cellular stress response and promote the cellular antioxidant defense. On one hand …
FOXO1 couples metabolic activity and growth state in the vascular endothelium
Endothelial cells (ECs) are plastic cells that can switch between growth states with different
bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues …
bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues …