Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Context-specific regulation and function of mRNA alternative polyadenylation
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer
H Chen, J Yao, R Bao, Y Dong, T Zhang, Y Du… - Molecular cancer, 2021 - Springer
Background The four major RNA adenosine modifications, ie, m 6 A, m 1 A, alternative
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …
Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer
Enhancer RNA (eRNA) is a type of noncoding RNA transcribed from the enhancer. Although
critical roles of eRNA in gene transcription control have been increasingly realized, the …
critical roles of eRNA in gene transcription control have been increasingly realized, the …
Cross-talk between cuproptosis and ferroptosis regulators defines the tumor microenvironment for the prediction of prognosis and therapies in lung adenocarcinoma
Y Shen, D Li, Q Liang, M Yang, Y Pan, H Li - Frontiers in immunology, 2023 - frontiersin.org
Cuproptosis, a newly identified form of programmed cell death, plays vital roles in
tumorigenesis. However, the interconnectivity of cuproptosis and ferroptosis is poorly …
tumorigenesis. However, the interconnectivity of cuproptosis and ferroptosis is poorly …
[HTML][HTML] The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …
Comprehensive characterization of circular RNAs in~ 1000 human cancer cell lines
Background Human cancer cell lines are fundamental models for cancer research and
therapeutic strategy development. However, there is no characterization of circular RNAs …
therapeutic strategy development. However, there is no characterization of circular RNAs …
Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy
Tumour hypoxia is a major contributor to resistance to anticancer therapies. Given that the
results of hypoxia-targeted therapy trials have been disappointing, a more personalized …
results of hypoxia-targeted therapy trials have been disappointing, a more personalized …
Alternative Polyadenylation: a new frontier in post transcriptional regulation
Polyadenylation of pre-messenger RNA (pre-mRNA) specific sites and termination of their
downstream transcriptions are signaled by unique sequence motif structures such as …
downstream transcriptions are signaled by unique sequence motif structures such as …
[HTML][HTML] Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer
Y Zhu, S Wang, X **, M Zhang, X Liu, W Tang, P Cai… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Rationale: Long extracellular RNAs (exRNAs) in plasma can be profiled by new
sequencing technologies, even with low abundance. However, cancer-related exRNAs and …
sequencing technologies, even with low abundance. However, cancer-related exRNAs and …