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Single-cell proteomics enabled by next-generation sequencing or mass spectrometry
In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …
single cells has greatly advanced our understanding of the underlying heterogeneity of …
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …
exercise training are a potent stimulus for physiological adaptation in many organs …
The diversification of methods for studying cell–cell interactions and communication
No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
Map** the proteo-genomic convergence of human diseases
INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …
Deciphering cell–cell interactions and communication from gene expression
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …
functions. When cells do not properly interact or improperly decode molecular messages …
Unbiased spatial proteomics with single-cell resolution in tissues
Mass spectrometry (MS)-based proteomics has become a powerful technology to quantify
the entire complement of proteins in cells or tissues. Here, we review challenges and recent …
the entire complement of proteins in cells or tissues. Here, we review challenges and recent …
Cancer proteogenomics: current impact and future prospects
Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …
driver mutations and development of targeted therapies. But the functions of the vast majority …
Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2
Background Macrophages are innate immune cells with diverse functional and molecular
phenotypes. This diversity is largely unexplored at the level of single-cell proteomes …
phenotypes. This diversity is largely unexplored at the level of single-cell proteomes …
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation
Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in …
and deep sequencing. However, proteins are the main drivers of cellular function and in …