Signaling pathways in brain tumors and therapeutic interventions

S Li, C Wang, J Chen, Y Lan, W Zhang… - … and Targeted Therapy, 2023‏ - nature.com
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

Cancer stem cells: significance in origin, pathogenesis and treatment of glioblastoma

K Biserova, A Jakovlevs, R Uljanovs, I Strumfa - Cells, 2021‏ - mdpi.com
Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

E Nolan, VL Bridgeman, L Ombrato, A Karoutas… - Nature cancer, 2022‏ - nature.com
Radiotherapy is one of the most effective approaches to achieve tumor control in cancer
patients, although healthy tissue injury due to off-target radiation exposure can occur. In this …

[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015‏ - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Notch as a tumour suppressor

CS Nowell, F Radtke - Nature Reviews Cancer, 2017‏ - nature.com
The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

[HTML][HTML] Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

E Kim, M Kim, DH Woo, Y Shin, J Shin, N Chang… - Cancer cell, 2013‏ - cell.com
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …

Dissecting tumor growth: the role of cancer stem cells in drug resistance and recurrence

B Aramini, V Masciale, G Grisendi, F Bertolini, M Maur… - Cancers, 2022‏ - mdpi.com
Simple Summary Cancer is one of the most debated problems all over the world. Cancer
stem cells are considered responsible of tumor initiation, metastasis, drug resistance, and …

EMT, CTCs and CSCs in tumor relapse and drug-resistance

A Mitra, L Mishra, S Li - Oncotarget, 2015‏ - pmc.ncbi.nlm.nih.gov
Tumor relapse and metastasis are the primary causes of poor survival rates in patients with
advanced cancer despite successful resection or chemotherapeutic treatment. A primary …

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

S Hombach-Klonisch, M Mehrpour, S Shojaei… - Pharmacology & …, 2018‏ - Elsevier
Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

K Katsushima, A Natsume, F Ohka, K Shinjo… - Nature …, 2016‏ - nature.com
Targeting self-renewal is an important goal in cancer therapy and recent studies have
focused on Notch signalling in the maintenance of stemness of glioma stem cells (GSCs) …