Background Kinetochores are large multi-protein structures that assemble on centromeric
DNA (CEN DNA) and mediate the binding of chromosomes to microtubules. Comprising 125 …

The genetic analysis of Candida albicans, the major fungal pathogen of humans, is
hampered by its diploid genome, the absence of a normal sexual cycle, and a nonstandard …

Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the
transcriptional network controlling this regulon has only been well characterized in the yeast …

Mitochondrial dysfunction in Candida albicans is known to be associated with drug
susceptibility, cell wall integrity, phospholipid homeostasis, and virulence. In this study, we …

Candida albicans is a commensal of the human microbiota that can form biofilms on
implanted medical devices. These biofilms are tolerant to antifungals and to the host …

The human fungal pathogen Candida albicans can use proteins as the sole source of
nitrogen for growth. The secretion of aspartic proteinases, which have been shown to …

The packaging of eukaryotic genomes into nuclesomes plays critical roles in chromatin
organization and gene regulation. Studies in Saccharomyces cerevisiae indicate that …

Overexpression of MDR1, which encodes a membrane transport protein of the major
facilitator superfamily, is one mechanism by which the human fungal pathogen Candida …

Fungal opportunistic pathogens colonize various environments, from plants and wood to
human and animal tissue. Regarding human pathogens, one great challenge during …

In response to nitrogen starvation, the human fungal pathogen Candida albicans switches
from yeast to filamentous growth. This morphogenetic switch is controlled by the ammonium …