The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating
blood vessel formation and barrier function. Proper composition and function of the …

Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo
as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the …

Endocytosis is an essential component of cell motility, which facilitates the malignant
behavior of cancer. Sorting nexin (SNX) family members are associated with tumor …

Invadopodia are integrin-mediated adhesions with abundant PI (3, 4) P2. However, the
functional role of PI (3, 4) P2 in adhesion signaling remains unclear. Here, we find that the PI …

Glioblastoma, also known as glioblastoma multiforme (GBM), is a fast‐growing tumor and
the most aggressive brain malignancy. Proteasome subunit beta type‐8 (PSMB8) is one of …

Sorting nexins (SNXs) are a diverse group of cytoplasmic‐and membrane‐associated
phosphoinositide‐binding proteins containing the PX domain proteins. The function of SNX …

Epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2) phosphorylation
drives HER2-positive breast cancer cell proliferation. Enforced activation of phosphatases …

Molecular details of how endocytosis contributes to oncogenesis remain elusive. Our in
silico analysis of colorectal cancer (CRC) patients revealed stage-dependent alterations in …

SPOP, speckle-type POZ protein is a substrate adaptor protein of the Cullin-3/RING ubiquitin
E3 complex. The spop gene is the most commonly point mutated in human primary prostate …

We here perform a systematic bioinformatic analysis to uncover the role of sorting nexin
(SNX) family in clinical outcome of gastric cancer (GC). Comprehensive bioinformatic …