The programmed cell death (PCD) of develo** cells is considered an essential adaptive
process that evolved to serve diverse roles. We review the putative adaptive functions of …

Glial cells are key players in the proper formation and maintenance of the nervous system,
thus contributing to neuronal health and disease in humans. However, little is known about …

CNS glia have integral roles in directing axon migration of both vertebrates and insects. In
contrast, very little is known about the roles of PNS glia in axonal pathfinding. In vertebrates …

In Drosophila, the chromosomal region 75C1–2 contains at least three genes, reaper (rpr),
head involution defective (hid), and grim, that have important functions in the activation of …

Extracellular factors such as FGF and EGF control various aspects of morphogenesis,
patterning and cellular proliferation in both invertebrates and vertebrates. In most systems, it …

Morphology is a defining feature of neuronal identity. Like neurons, glia display diverse
morphologies, both across and within glial classes, but are also known to be …

The initiator caspase Dronc is the only Drosophila caspase that contains a caspase
activation and recruitment domain (CARD). Although Dronc has been implicated as an …

Trophic mechanisms in which neighboring cells mutually control their survival by secreting
extracellular factors play an important role in determining cell number. However, how trophic …

Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been
found. Neurotrophins are the main vertebrate secreted signalling molecules that link …

How is cell fate diversity reliably achieved during development? Insect sensory organs have
been a favorable model system for investigating this question for over 100 years. They are …