Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis

J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …

Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity

X Su, Y Gao, R Yang - Frontiers in immunology, 2023 - frontiersin.org
Bile acids (BAs) as cholesterol-derived molecules play an essential role in some
physiological processes such as nutrient absorption, glucose homeostasis and regulation of …

The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism

Y Shu, Y Huang, W Dong, X Fan, Y Sun, G Chen… - International Journal of …, 2023 - Elsevier
The polysaccharides from Auricularia auricula (AAPs), containing a large number of O-acetyl
groups that are related to the physiological and biological properties, seem to be potential …

[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

The roles of gut microbiota and its metabolites in diabetic nephropathy

H Zhao, CE Yang, T Liu, MX Zhang, Y Niu… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which
increases the risk of renal failure and causes a high global disease burden. Due to the lack …

Non-alcoholic fatty liver disease and gut microbial dysbiosis-underlying mechanisms and gut microbiota mediated treatment strategies

M Jayachandran, S Qu - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Non-alcoholic fatty liver disease (NAFLD) is by far the most prevalent form of liver disease
worldwide. It's also the leading cause of liver-related hospitalizations and deaths …

Bile acid-mediated signaling in cholestatic liver diseases

J Zeng, J Fan, H Zhou - Cell & Bioscience, 2023 - Springer
Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary
sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to …

FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

K Wang, Y Zhang, G Wang, H Hao… - Medicinal Research …, 2024 - Wiley Online Library
Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver
disease, is the most common liver disease worldwide and has no approved …

Fecal microbiota transplantation in NAFLD treatment

L Abenavoli, V Maurizi, E Rinninella, J Tack… - Medicina, 2022 - mdpi.com
Introduction: Gut microbiota is not only a taxonomic biologic ecosystem but is also involved
in human intestinal and extra-intestinal functions such as immune system modulation …

[HTML][HTML] Primary sclerosing cholangitis and overlap features of autoimmune hepatitis: a coming of age or an age-ist problem?

A Ricciuto, BM Kamath, GM Hirschfield, PJ Trivedi - Journal of Hepatology, 2023 - Elsevier
Autoimmune liver diseases are siloed into three syndromes that define clinical practice.
These classifiers can, and are, challenged by variant presentations across all ages …