I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by a type 2
immune signature often have severe and recurrent disease. Lower airway conditions such …

Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant
morbidity and costs to our health system. The study of CRS has progressed from an era …

Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …

Contributing Authors Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham,
MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav …

Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …

Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an important clinical entity diagnosed
by the presence of both subjective and objective evidence of chronic sinonasal …

Chronic rhinosinusitis (CRS) is a troublesome, chronic inflammatory disease that affects
over 10% of the adult population, causing decreased quality of life, lost productivity, and lost …