The C. elegans model in toxicity testing

PR Hunt - Journal of Applied Toxicology, 2017 - Wiley Online Library
Caenorhabditis elegans is a small nematode that can be maintained at low cost and
handled using standard in vitro techniques. Unlike toxicity testing using cell cultures, C …

Coding or noncoding, the converging concepts of RNAs

J Li, C Liu - Frontiers in genetics, 2019 - frontiersin.org
Technological advances over the past decade have unraveled the remarkable complexity of
RNA. The identification of small peptides encoded by long non-coding RNAs (lncRNAs) as …

OrthoVenn3: an integrated platform for exploring and visualizing orthologous data across genomes

J Sun, F Lu, Y Luo, L Bie, L Xu, Y Wang - Nucleic acids research, 2023 - academic.oup.com
Advancements in comparative genomics research have led to a growing interest in studying
species evolution and genetic diversity. To facilitate this research, OrthoVenn3 has been …

CAFE 5 models variation in evolutionary rates among gene families

FK Mendes, D Vanderpool, B Fulton, MW Hahn - Bioinformatics, 2020 - academic.oup.com
Motivation Genome sequencing projects have revealed frequent gains and losses of genes
between species. Previous versions of our software, Computational Analysis of gene Family …

Classification and function of small open reading frames

JP Couso, P Patraquim - Nature reviews Molecular cell biology, 2017 - nature.com
Small open reading frames (smORFs) of 100 codons or fewer are usually—if arbitrarily—
excluded from proteome annotations. Despite this, the genomes of many metazoans …

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

A Aspatwar, MEE Tolvanen, H Barker… - Physiological …, 2022 - journals.physiology.org
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

Developmental genetics with model organisms

U Irion, C Nüsslein-Volhard - Proceedings of the National Academy of …, 2022 - pnas.org
In Darwin's and Mendel's times, researchers investigated a wealth of organisms, chosen to
solve particular problems for which they seemed especially well suited. Later, a focus on a …

Drosophila as an In Vivo Model for Human Neurodegenerative Disease

L McGurk, A Berson, NM Bonini - Genetics, 2015 - academic.oup.com
With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

The developmental transcriptome of Drosophila melanogaster

BR Graveley, AN Brooks, JW Carlson, MO Duff… - Nature, 2011 - nature.com
Drosophila melanogaster is one of the most well studied genetic model organisms;
nonetheless, its genome still contains unannotated coding and non-coding genes …

Initial sequencing and analysis of the human genome

US DOE Joint Genome Institute: Hawkins Trevor 4 … - nature, 2001 - nature.com
The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …