Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …

Background Idiopathic hypereosinophilic syndrome involves a prolonged state of
eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

FLT3 receptor tyrosine kinase is expressed on lymphoid and myeloid progenitors in the
hematopoietic system. Activating mutations in FLT3 have been identified in approximately …

Myeloid malignancies are clonal disorders that are characterized by acquired somatic
mutation in hematopoietic progenitors. Recent advances in our understanding of the genetic …

Blood eosinophilia signifies either a cytokine‐mediated reactive phenomenon (secondary)
or an integral phenotype of an underlying haematological neoplasm (primary). Secondary …

A recurrent somatic activating mutation in the nonreceptor tyrosine kinase JAK2
(JAK2V617F) occurs in the majority of patients with the myeloproliferative disorders …

Idiopathic hypereosinophilic syndrome (HES) and chronic eosinophilic leukemia (CEL)
comprise a spectrum of indolent to aggressive diseases characterized by unexplained …

Constitutive activation of tyrosine kinases, such as the BCR/ABL fusion associated with t (9;
22)(q34; q22), is a hallmark of chronic myeloid leukemia (CML) syndromes in humans …