Mitochondrial membrane lipids in the regulation of bioenergetic flux
Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …
Reign in the membrane: How common lipids govern mitochondrial function
The lipids that make up biological membranes tend to be the forgotten molecules of cell
biology. The paucity of data on these important entities likely reflects the difficulties of …
biology. The paucity of data on these important entities likely reflects the difficulties of …
Cardiolipin-targeted NIR-II fluorophore causes “avalanche effects” for re-engaging cancer apoptosis and inhibiting metastasis
H Bian, D Ma, F Pan, X Zhang, K **n… - Journal of the …, 2022 - ACS Publications
Restoring innate apoptosis and simultaneously inhibiting metastasis by a molecular drug is
an effective cancer therapeutic approach. Herein, a large rigid and V-shaped NIR-II dye …
an effective cancer therapeutic approach. Herein, a large rigid and V-shaped NIR-II dye …
Mitochondrial protein interaction landscape of SS-31
Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including
heart disease, cancer, neurodegenerative diseases, and the general aging process …
heart disease, cancer, neurodegenerative diseases, and the general aging process …
Phospholipid ebb and flow makes mitochondria go
Mitochondria, so much more than just being energy factories, also have the capacity to
synthesize macromolecules including phospholipids, particularly cardiolipin (CL) and …
synthesize macromolecules including phospholipids, particularly cardiolipin (CL) and …
How cardiolipin modulates the dynamics of respiratory complex I
Cardiolipin modulates the activity of membrane-bound respiratory enzymes that catalyze
biological energy transduction. The respiratory complex I functions as the primary redox …
biological energy transduction. The respiratory complex I functions as the primary redox …
Dynamic cardiolipin synthesis is required for CD8+ T cell immunity
Mitochondria constantly adapt to the metabolic needs of a cell. This mitochondrial plasticity
is critical to T cells, which modulate metabolism depending on antigen-driven signals and …
is critical to T cells, which modulate metabolism depending on antigen-driven signals and …
Position-dependent diffusion tensors in anisotropic media from simulation: oxygen transport in and through membranes
A Bayesian-based methodology is developed to estimate diffusion tensors from molecular
dynamics simulations of permeants in anisotropic media, and is applied to oxygen in lipid …
dynamics simulations of permeants in anisotropic media, and is applied to oxygen in lipid …
Cobra venom cytotoxins as a tool for probing mechanisms of mitochondrial energetics and understanding mitochondrial membrane structure
In this paper, we provide an overview of mitochondrial bioenergetics and specific conditions
that lead to the formation of non-bilayer structures in mitochondria. Secondly, we provide a …
that lead to the formation of non-bilayer structures in mitochondria. Secondly, we provide a …
TAZ encodes tafazzin, a transacylase essential for cardiolipin formation and central to the etiology of Barth syndrome
Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature
cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from …
cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from …