Reactive hyperemia is a well-established technique for noninvasive assessment of
peripheral microvascular function and a predictor of all-cause and cardiovascular morbidity …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

Renal arteries (RAs) dilate in response to hypoxia, whereas the pulmonary arteries (PAs)
constrict. In the PA, O2 tension is detected by an unidentified redox sensor, which controls …

Potassium channels play an essential role in the membrane potential of arterial smooth
muscle, and also in regulating contractile tone. Four types of K+ channel have been …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …

Abstract Large-conductance, Ca 2+-activated K+(BK Ca) channels in smooth muscle cells
are unique because they integrate changes in both intracellular Ca 2+ and membrane …

The cellular mechanisms that determine differences in reactivity of arteries of varying size
and origin are unknown. We evaluated the hypothesis that there is diversity in the …

Background Hyperpolarization of vascular muscle in response to activation of potassium
channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different …

The ability to sense and respond to oxygen deprivation is required for survival; thus,
understanding the mechanisms by which changes in oxygen are linked to cell viability and …