The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Antibiotic development based on natural products has faced a long lasting decline since the
1970s, while both the speed and the extent of antimicrobial resistance (AMR) development …

Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …

Bacterial resistance has become increasingly serious because of the widespread use and
abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a …

Tuberculosis is a highly infectious disease other than HIV/AIDS and it is one of the top ten
causes of death worldwide. Resistance development in the bacteria occurs because of …

Epidemic diseases and antibiotic resistance are urgent threats to global health, and human
is confronted with an unprecedented dilemma to conquer them by expediting development …

The natural phenomenon of drug resistance is a widespread issue that hampers the
performance of drugs in many major clinical indications. Antibacterial and antifungal drugs …

ABSTRACT The World Health Organization has categorized the Gram-negative superbugs,
which are inherently impervious to many antibiotics, as critical priority pathogens due to the …

Abstract Adenosine Triphosphate synthase (ATPs) is an important enzyme for the synthesis
of adenosine triphosphate (ATP). ATP is principal source of energy for growth and …