Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

IL-17 signaling: the yin and the yang

N Amatya, AV Garg, SL Gaffen - Trends in immunology, 2017 - cell.com
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

IL-17 receptor–based signaling and implications for disease

X Li, R Bechara, J Zhao, MJ McGeachy… - Nature immunology, 2019 - nature.com
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …

Human inborn errors of immunity: an expanding universe

LD Notarangelo, R Bacchetta, JL Casanova… - Science …, 2020 - science.org
Molecular, cellular, and clinical studies of human inborn errors of immunity have
revolutionized our understanding of their pathogenesis, considerably broadened their …

Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria

Q Philippot, M Ogishi, J Bohlen, J Puchan… - Science …, 2023 - science.org
Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

J Toubiana, S Okada, J Hiller… - Blood, The Journal …, 2016 - ashpublications.org
Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous
candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have …

Interleukin-17A and keratinocytes in psoriasis

M Furue, K Furue, G Tsuji, T Nakahara - International journal of molecular …, 2020 - mdpi.com
The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates
a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates …

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

S Okada, JG Markle, EK Deenick, F Mele, D Averbuch… - Science, 2015 - science.org
Human inborn errors of immunity mediated by the cytokines interleukin-17A and interleukin-
17F (IL-17A/F) underlie mucocutaneous candidiasis, whereas inborn errors of interferon-γ …

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

DG McGonagle, IB McInnes, BW Kirkham… - Annals of the …, 2019 - ard.bmj.com
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …