[BOK][B] RNA, the epicenter of genetic information
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
Non‐coding RNAs to treat vascular smooth muscle cell dysfunction
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
F Fasolo, H **, G Winski, E Chernogubova, J Pauli… - Circulation, 2021 - Am Heart Assoc
Background: Long noncoding RNAs (lncRNAs) are important regulators of biological
processes involved in vascular tissue homeostasis and disease development. The present …
processes involved in vascular tissue homeostasis and disease development. The present …
CARMN Is an Evolutionarily Conserved Smooth Muscle Cell–Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin
Background: Vascular homeostasis is maintained by the differentiated phenotype of
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
vascular smooth muscle cells (VSMCs). The landscape of protein coding genes comprising …
Phenotypic switching of vascular smooth muscle cells in atherosclerosis
R Chen, DG McVey, D Shen, X Huang… - Journal of the American …, 2023 - Am Heart Assoc
The medial layer of the arterial wall is composed mainly of vascular smooth muscle cells
(VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their …
(VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their …
A smooth muscle cell–enriched long noncoding rna regulates cell plasticity and atherosclerosis by interacting with serum response factor
Objective: Vascular smooth muscle cell (VSMC) plasticity plays a critical role in the
development of atherosclerosis. Long noncoding RNAs (lncRNAs) are emerging as …
development of atherosclerosis. Long noncoding RNAs (lncRNAs) are emerging as …
Loss of hepatic angiotensinogen attenuates sepsis-induced myocardial dysfunction
J Rong, X Tao, Y Lin, H Zheng, L Ning, HS Lu… - Circulation …, 2021 - Am Heart Assoc
Rationale: The renin-angiotensin system is a complex regulatory network that maintains
normal physiological functions. The role of the renin-angiotensin system in sepsis-induced …
normal physiological functions. The role of the renin-angiotensin system in sepsis-induced …
Non-coding RNAs in regulating plaque progression and remodeling of extracellular matrix in atherosclerosis
Non-coding RNAs (ncRNAs) regulate cell proliferation, migration, differentiation,
inflammation, metabolism of clinically important biomolecules, and other cellular processes …
inflammation, metabolism of clinically important biomolecules, and other cellular processes …
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53‐driven tumour progression through miR‐5683/FGF2
N Liu, X Jiang, G Zhang, S Long, J Li… - Clinical and …, 2024 - Wiley Online Library
Abstract N‐methyladenosine (m6A) represents a prevalent RNA modification observed in
colorectal cancer. Despite its abundance, the biological implications of m6A methylation on …
colorectal cancer. Despite its abundance, the biological implications of m6A methylation on …
LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis
S Li, RC He, SG Wu, Y Song, KL Zhang… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Increasing evidence suggests that long noncoding RNAs play significant
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …
roles in vascular biology and disease development. One such long noncoding RNA, PSMB8 …