Simple Summary Clinical management in neuro-oncology has shifted to an integrated
method that combines molecular profiles with histopathological and imaging data. Liquid …

Recently, emerging evidence has demonstrated that cavitation actually creates important
bidirectional channels on biological barriers for both intratumoral drug delivery and …

Simple Summary Diagnosing brain tumors using minimally invasive methods, such as a
liquid biopsy, is challenging due to the blood–brain barrier (BBB). The BBB blocks tumor …

Background Neurodegenerative disorders (such as Alzheimer disease) characterized by the
deposition of various pathogenic forms of tau protein in the brain are collectively referred to …

Background Highly sensitive molecular assays have been developed to detect plasma-
based circulating tumor DNA (ctDNA), and emerging evidence suggests their clinical utility …

Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical
trials in glioblastoma (GBM) patients. Ultrasound-mediated blood–brain barrier opening …

Monitoring CNVs and hotspot mutations by liquid biopsy is a promising tool to detect
minimal residual disease and strengthen response assessment in patients with primary …

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The diagnosis of brain tumors typically relies on magnetic resonance imaging (MRI),
computed tomography (CT), and invasive procedures like biopsies or surgical resection for …

Background: The blood-brain barrier (BBB) impedes the passage of most circulating drugs
into the brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently …