Extracellular HtrA serine proteases: an emerging new strategy in bacterial pathogenesis

S Backert, S Bernegger, J Skórko‐Glonek… - Cellular …, 2018 - Wiley Online Library
The HtrA family of chaperones and serine proteases is important for regulating stress
responses and controlling protein quality in the periplasm of bacteria. HtrA is also …

Extracellular vesicles with possible roles in gut intestinal tract homeostasis and IBD

X Chang, SL Wang, SB Zhao, YH Shi… - Mediators of …, 2020 - Wiley Online Library
The intestinal tract consists of various types of cells, such as epithelial cells, Paneth cells,
macrophages, and lymphocytes, which constitute the intestinal immune system and play a …

Campylobacter jejuni Surface-Bound Protease HtrA, but Not the Secreted Protease nor Protease in Shed Membrane Vesicles, Disrupts Epithelial Cell-to-Cell …

I Sharafutdinov, N Tegtmeyer, M Rohde, A Olofsson… - Cells, 2024 - mdpi.com
Fundamental functions of the intestinal epithelium include the digestion of food, absorption
of nutrients, and its ability to act as the first barrier against intruding microbes …

Trimer stability of Helicobacter pylori HtrA is regulated by a natural mutation in the protease domain

U Zarzecka, N Tegtmeyer, H Sticht… - Medical Microbiology and …, 2023 - Springer
The human pathogen Helicobacter pylori is a major risk factor for gastric disease
development. Serine protease HtrA is an important bacterial virulence factor that cleaves the …

[HTML][HTML] The role played by bacterial infections in the onset and metastasis of cancer

S Khatun, T Appidi, AK Rengan - Current Research in Microbial Sciences, 2021 - Elsevier
Understanding various responses of cells towards change in their external environment,
presence of other species and is important in identifying and correlating the mechanisms …

[HTML][HTML] Molecular structures mediating adhesion of Campylobacter jejuni to abiotic and biotic surfaces

J Sabotič, N Janež, M Volk, A Klančnik - Veterinary microbiology, 2023 - Elsevier
Abstract Microaerophilic, Gram-negative Campylobacter jejuni is the causative agent of
campylobacteriosis, the most common bacterial gastrointestinal infection worldwide …

Function of serine protease HtrA in the lifecycle of the foodborne pathogen Campylobacter jejuni

M Boehm, D Simson, U Escher, AM Schmidt… - European Journal of …, 2018 - akjournals.com
Campylobacter jejuni is a major food-borne zoonotic pathogen, responsible for a large
proportion of bacterial gastroenteritis cases, as well as Guillian-Barré and Miller-Fisher …

Environment Controls LEE Regulation in Enteropathogenic Escherichia coli

A Platenkamp, JL Mellies - Frontiers in microbiology, 2018 - frontiersin.org
Enteropathogenic Escherichia coli (EPEC) is a significant cause of infant morbidity and
mortality in develo** regions of the world. Horizontally acquired genetic elements encode …

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

A Harrer, M Boehm, S Backert, N Tegtmeyer - Gut pathogens, 2017 - Springer
Abstract Background The serine protease HtrA is an important factor for regulating stress
responses and protein quality control in bacteria. In recent studies, we have demonstrated …

Host cell-surface proteins as substrates of gingipains, the main proteases of Porphyromonas gingivalis

K Hočevar, J Potempa, B Turk - Biological chemistry, 2018 - degruyter.com
Gingipains are extracellular cysteine proteases of the oral pathogen Porphyromonas
gingivalis and are its most potent virulence factors. They can degrade a great variety of host …