Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-
ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific …

Signalling by ubiquitination regulates virtually every cellular process in eukaryotes. Covalent
attachment of ubiquitin to a substrate is catalysed by the E1, E2 and E3 three-enzyme …

ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls
many cellular processes, including DNA repair, transcription, chromatin regulation and …

Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

Poly-ADP-ribose metabolism plays a mayor role in a wide range of biological processes,
such as maintenance of genomic stability, transcriptional regulation, energy metabolism and …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

The functionality of DNA, RNA and proteins is altered dynamically in response to
physiological and pathological cues, partly achieved by their modification. While the …

T cells express a toxin-related ADP-ribosylating ectoenzyme, ART2. Exposure of mature T
cells to NAD, the substrate for ADP-ribosylation, induces cell death. ART2-catalyzed ADP …