Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

H Li, H Kim, F Xu, J Han, Q Yao, J Wang, K Pu… - Chemical Society …, 2022 - pubs.rsc.org
The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …

Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment

K Graham, E Unger - International journal of nanomedicine, 2018 - Taylor & Francis
Hypoxia exists to some degree in most solid tumors due to inadequate oxygen delivery of
the abnormal vasculature which cannot meet the demands of the rapidly proliferating cancer …

Hypoxia-targeted drug delivery

A Sharma, JF Arambula, S Koo, R Kumar… - Chemical Society …, 2019 - pubs.rsc.org
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

SR McKeown - The British journal of radiology, 2014 - academic.oup.com
Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia

L Zheng, CJ Kelly, SP Colgan - American Journal of …, 2015 - journals.physiology.org
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …

Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis

X Li, Y Jiang, J Meisenhelder, W Yang, DH Hawke… - Molecular cell, 2016 - cell.com
It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is
coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that …

Glioma stem cells and their roles within the hypoxic tumor microenvironment

NH Boyd, AN Tran, JD Bernstock, T Etminan… - …, 2021 - pmc.ncbi.nlm.nih.gov
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Targeting hypoxia to improve non–small cell lung cancer outcome

A Salem, MC Asselin, B Reymen… - JNCI: Journal of the …, 2018 - academic.oup.com
Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

[HTML][HTML] Inflammatory mechanisms of HCC development

MG Refolo, C Messa, V Guerra, BI Carr… - Cancers, 2020 - mdpi.com
HCC (hepatocellular carcinoma) is the second leading cause of cancer deaths worldwide,
with several etiologic causes, mostly inflammation-associated. Different inflammatory …