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Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …
physiology and pathology in living systems, making significant contributions to life science …
Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook
The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …
dye with high structural tailorability is of great significance in the field of detection …
Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment
K Graham, E Unger - International journal of nanomedicine, 2018 - Taylor & Francis
Hypoxia exists to some degree in most solid tumors due to inadequate oxygen delivery of
the abnormal vasculature which cannot meet the demands of the rapidly proliferating cancer …
the abnormal vasculature which cannot meet the demands of the rapidly proliferating cancer …
Hypoxia-targeted drug delivery
Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …
associated with abnormal vasculature, which results in a reduced supply of oxygen and …
Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
SR McKeown - The British journal of radiology, 2014 - academic.oup.com
Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …
as it compromises treatment and drives malignant progression. This review seeks to clarify …
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …
Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis
It is unclear how the Warburg effect that exemplifies enhanced glycolysis in the cytosol is
coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that …
coordinated with suppressed mitochondrial pyruvate metabolism. We demonstrate here that …
Glioma stem cells and their roles within the hypoxic tumor microenvironment
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …
unrestricted growth and proliferation and result in further modifications in cell behavior …
Targeting hypoxia to improve non–small cell lung cancer outcome
Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …
[HTML][HTML] Inflammatory mechanisms of HCC development
MG Refolo, C Messa, V Guerra, BI Carr… - Cancers, 2020 - mdpi.com
HCC (hepatocellular carcinoma) is the second leading cause of cancer deaths worldwide,
with several etiologic causes, mostly inflammation-associated. Different inflammatory …
with several etiologic causes, mostly inflammation-associated. Different inflammatory …