Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that
can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic …

The compositional asymmetry of biological membranes has attracted significant attention
over the last decade. Harboring more differences from symmetric membranes than …

We have determined the partial leaflet–leaflet phase diagram of an asymmetric lipid bilayer
at ambient temperature using asymmetric giant unilamellar vesicles (aGUVs). Symmetric …

Almost all biomembranes are constructed as lipid bilayers and, in almost all of these, the two
opposing monolayers (leaflets) have distinct lipid compositions. This lipid asymmetry arises …

Peptide–lipid interactions play an important role in defining the mode of action of drugs and
the molecular mechanism associated with many diseases. Model membranes consisting of …

Many cellular lipid bilayers consist of leaflets that differ in their lipid composition—a non-
equilibrium state actively maintained by cellular sorting processes that counter passive lipid …

The activity of integral membrane proteins is tightly coupled to the properties of the
surrounding lipid matrix. In particular, transbilayer asymmetry, a hallmark of all plasma …

Cholesterol is a biological molecule that is essential for cellular life. It has unique features in
terms of molecular structure and function, and plays an important role in determining the …

One persistent puzzle in the life sciences is the asymmetric lipid composition of the cellular
plasma membrane: while the exoplasmic leaflet is enriched in lipids carrying predominantly …

In contrast to symmetric unilamellar liposomes (sLUVs) prepared from a mixture of different
lipids, asymmetric ones (aLUVs) with different lipid composition in the inner and outer …