Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events

D Mozaffarian, JHY Wu - Journal of the American College of Cardiology, 2011 - jacc.org
We reviewed available evidence for cardiovascular effects of n-3 polyunsaturated fatty acid
(PUFA) consumption, focusing on long chain (seafood) n-3 PUFA, including their principal …

Cardiovascular effects of marine omega-3 fatty acids

P Saravanan, NC Davidson, EB Schmidt, PC Calder - The Lancet, 2010 - thelancet.com
Much evidence shows that the marine omega-3 fatty acids eicosapentaenoic acid and
docosahexaenoic acid have beneficial effects in various cardiac disorders, and their use is …

Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids

SM Innis - The Journal of pediatrics, 2003 - Elsevier
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are important structural
components of the central nervous system. These fatty acids are transferred across the …

[HTML][HTML] (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?

D Mozaffarian, JHY Wu - The Journal of nutrition, 2012 - Elsevier
Considerable research supports cardiovascular benefits of consuming omega-3 PUFA, also
known as (n-3) PUFA, from fish or fish oil. Whether individual long-chain (n-3) PUFA have …

Inhibitors of connexin and pannexin channels as potential therapeutics

J Willebrords, M Maes, SC Yanguas… - Pharmacology & …, 2017 - Elsevier
While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Cardioprotective actions of grape polyphenols

WR Leifert, MY Abeywardena - Nutrition Research, 2008 - Elsevier
The aim of this review is to discuss the accumulating evidence that suggests that grape
extracts and purified grape polyphenols possess a diverse array of biological actions and …

Membrane interactions of phytochemicals as their molecular mechanism applicable to the discovery of drug leads from plants

H Tsuchiya - Molecules, 2015 - mdpi.com
In addition to interacting with functional proteins such as receptors, ion channels, and
enzymes, a variety of drugs mechanistically act on membrane lipids to change the …

Sodium channel inactivation: molecular determinants and modulation

W Ulbricht - Physiological reviews, 2005 - journals.physiology.org
Voltage-gated sodium channels open (activate) when the membrane is depolarized and
close on repolarization (deactivate) but also on continuing depolarization by a process …

[HTML][HTML] Polyunsaturated fatty acids and their effects on cardiovascular disease

BP Ander, CMC Dupasquier, MA Prociuk… - … & Clinical Cardiology, 2003 - ncbi.nlm.nih.gov
Dietary polyunsaturated fatty acids (PUFAs) affect a wide variety of physiological processes.
Much attention has been given to the n-3 PUFAs and their role in the prevention and …

Actions and mechanisms of polyunsaturated fatty acids on voltage-gated ion channels

F Elinder, SI Liin - Frontiers in physiology, 2017 - frontiersin.org
Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …