Pharmacological potential of betulin as a multitarget compound

FO Adepoju, KC Duru, E Li, EG Kovaleva, MV Tsurkan - Biomolecules, 2023 - mdpi.com
Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing
properties. Despite having a wide range of pharmacological targets, no studies have …

Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions

HS Tuli, R Joshi, G Kaur, VK Garg, K Sak… - Journal of Nanostructure …, 2023 - Springer
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for
therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) …

Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives

S Datta, D Aggarwal, N Sehrawat, M Yadav, V Sharma… - Phytomedicine, 2023 - Elsevier
Background: The liver is a well-known player in the metabolism and removal of drugs. Drug
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …

[HTML][HTML] Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection

HS Tuli, VK Garg, S Bhushan, V Uttam, U Sharma… - Translational …, 2023 - Elsevier
Cancer prevalence and its rate of incidence are constantly rising since the past few
decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore …

[HTML][HTML] New light on treatment of cervical cancer: Chinese medicine monomers can be effective for cervical cancer by inhibiting the PI3K/Akt signaling pathway

F Liu, J Xu, R Yang, S Liu, S Hu, M Yan… - Biomedicine & …, 2023 - Elsevier
Cervical cancer (CC), as the most common malignant tumor of the female reproductive
system, is infamous for its high morbidity and mortality rates. Its development and metastasis …

Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms

EM Bajalia, FB Azzouz, DA Chism, DM Giansiracusa… - Cancers, 2022 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most frequently diagnosed kidney
cancer. Once RCC metastasizes, successful treatment is difficult to achieve. There is an …

[HTML][HTML] Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model

T Ouyang, H Yin, J Yang, Y Liu, S Ma - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Betulin is the primary anti-inflammatory component of Betula platyphylla suk. cortex (birch
bark), a time-honored Traditional Chinese Medicine (TCM) for healing trauma and tissue …

Betulin and its derivatives reduce inflammation and COX-2 activity in macrophages

W Szlasa, S Ślusarczyk, I Nawrot-Hadzik, R Abel… - Inflammation, 2023 - Springer
Betulin is a heavily studied natural compound for its use as an anticancer or pro-
regenerative agent. The structural similarity between betulin to steroids gives rise to the idea …

Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects

N Casarcia, P Rogers, E Guld, S Iyer… - British Journal of …, 2023 - Wiley Online Library
Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States,
owing to its aggressive nature and suboptimal treatment options, emphasizing the need for …

Recent progress on triterpenoid derivatives and their anticancer potential

ZX Zhao, QY Zou, YH Ma, SL Morris‐Natschke, XY Li… - Phytochemistry, 2024 - Elsevier
Cancer poses a significant global public health challenge, with commonly used adjuvant or
neoadjuvant chemotherapy often leading to adverse side effects and drug resistance …