Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …

Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

SUMOylation, which is a type of post-translational modification that involves covalent
conjugation of small ubiquitin-like modifier (SUMO) proteins to target substrates, regulates …

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …

During chronic infection and cancer, a self-renewing CD8+ T cell subset maintains long-term
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8+ T cells …

Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding
how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and …